SQSTM1 and atherosclerosis: Our characterization of mφTFEB-TG mice in vivo and cultured macrophages in vitro demonstrates TFEB's ability to increase macrophage autophagy and autophagy–lysosomal biogenesis, increase aggrephagy and the clearance of p62-enriched protein aggregates, decrease macrophage apoptosis and the pro-inflammatory cytokine IL-1β, and decrease atherosclerosis and plaque complexity.