AKT1 and cancer: A pathway over-representation analysis using ConsensusPathDB (CPDB) [26] showed that 120 genes were significantly over-represented in 23 Reactome pathways (FDR q < 0.05), including many cancer-related pathways such as PI3K/AKT activation, oncogene induced senescence, repression of WNT target genes, etc. (Table 3).