HLA-DRB1*1501:    •  risk for MS    •  early disease onset.    •  risk for progression from RRMS to SPMSHLA-DPB1* 0501 & HLA-DPB1* 0301:    •  risk for opticospinal MS.HLA-DRB1* 1501 & HLA-DQB1* 0301:    •  worst brain atrophy measures.DR3 & DR4 haplotypes:    •  risk for MS.TOB1 gen:    •  early conversion from CIS to CDMS.ApoEƐ4:    •  greater risk for mental disorders.Pharmacogenomics. The gene discussed is HLA-DQB1; the disease is in situ carcinoma.