Generation of cytokines from human Kupffer cells results in the overexpression of cell adhesion molecules such as ICAM-1, VCAM-1, and E-selectin in endothelial cells which can be detected in a multicell coculture system incubated with CEA-producing colon cancer cells, Kupffer cells, and endothelial cells [26, 84]. The gene discussed is CEACAM5; the disease is malignant colon neoplasm.