Only recently a case of familial spastic paraplegia has been linked to an ATP2B4 mutation (Ho et al., 2015; http://omim.org/entry/108732), and while Atp2b4-null mice have no overt phenotype, the male mice are infertile due to reduced sperm motility (Okunade et al., 2004; Schuh et al., 2004; Kim et al., 2012). This evidence concerns the gene ATP2B4 and hereditary spastic paraplegia.