In a recent study (Gong et al., 2016), we investigated the effects of pre-treatment of rats with ad-hepcidin on iron contents and iron-mediated free radical reaction and demonstrated that ad-hepcidin could prevent the increase in iron content as well as the level of dichlorofluorescein and 8-isoprostane, two reliable indicators of ROS in different brain regions of iron-overload rats. Here, HAMP is linked to Tangier disease.