LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for herpes virus entry on T cells) is a TNF core family member that is involved in the pathogenesis of human IBD (Krause et al., 2014), and in cultured epithelia, MLCK inhibition alleviated LIGHT-induced barrier loss, which suggested that LIGHT-induced epithelial barrier loss may depend on MLCK activation (Schwarz et al., 2007). Here, TNF is linked to inflammatory bowel disease.