Abnormal expression of MLCK has been observed in many inflammatory diseases including pancreatitis (Shi et al., 2014), respiratory diseases (Zhou et al., 2015), cardiovascular diseases (Cheng et al., 2015), cancer (Zhou et al., 2014), and inflammatory bowel disease (IBD) (Yi et al., 2014). This evidence concerns the gene MYLK2 and inflammatory bowel disease.