For example, P2X4 are implicated in neuropathic pain (Tsuda et al., 2003, 2009a; Coull et al., 2005; Ulmann et al., 2008), inflammatory pain (Ulmann et al., 2010), epilepsy (Ulmann et al., 2013), lung surfactant secretion (Miklavc et al., 2013), alcohol intake and preference (Wyatt et al., 2014; Franklin et al., 2015), morphine-induced hyperalgesia (Ferrini et al., 2013), cardiac function (Yang et al., 2014) and P2X4 deficiency is associated with sociocommunicative impairments (Wyatt et al., 2013) and altered flow-dependent blood vessel remodeling (Yamamoto et al., 2006). The gene discussed is P2RX4; the disease is epilepsy.