IL1B and ulcer disease: In an open-label, proof of concept study evaluating the anti-IL-1β monoclonal antibody Gevokizumab, six patients with active ulcers received three subcutaneous injections once every 4 weeks and four out of six patients had a complete clearance of the target ulcer, 1 a partial (90%) closure of the ulcer and 1 did not respond (ClinicalTrials.gov Identifier: NCT01882504) (Huang et al., 2014, poster).