The studied clock gene CLOCK (Circadian Locomotor Output Cycles Kaput) and its binding partner BMAL1 (also known as Aryl hydrocarbon receptor nuclear translocator-like protein 1 or ARNTL1) were associated with bipolar disorder phenomena in genetic studies (Roybal et al., 2007; McCarthy and Welsh, 2012; Young and Dulcis, 2015). The gene discussed is CLOCK; the disease is bipolar disorder.