In some epileptic patients and “long-term” animal models of epilepsy, a significant reduction of SV2A is observed, supporting the idea that SV2A could endorse a role in epilepsy progression (Feng et al., 2009; Toering et al., 2009; van Vliet et al., 2009; Hanaya et al., 2012). The gene discussed is SV2A; the disease is epilepsy.