For instance, basic fibroblast growth factor (bFGF) is a composition of mucus in COPD patients, which shows an ability to significantly induce the expression of β-catenin, Wnt5A, and RhoA in primary fibroblasts of rats COPD model, in comparison with fibroblasts from rats without COPD. Here, FGF2 is linked to chronic obstructive pulmonary disease.