A clinical association study by Lam et al. further revealed that the expression of Wnt signaling coreceptors LRP5/6 of peripheral blood mononuclear cells (PBMCs) and Wnt signaling receptor FZD8 of IPF lung tissues were elevated in IPF patients, suggesting that they were independent factors associated with IPF disease progression and severity [66]. Here, FZD8 is linked to idiopathic pulmonary fibrosis.