However, activating Wnt/β-catenin signaling was required for TGF-β/Smad2/3 signaling during myofibroblast proliferation, suggesting that Wnt/β-catenin-activated TGF-β/Smad2/3 signaling in epithelial and mesenchymal cells contributed to lung fibrosis [68]. The gene discussed is SMAD2; the disease is pulmonary fibrosis.