Experimentally, mice with deficient LRP5 or direct inhibition of β-catenin signaling by small molecular inhibitor showed a resistance to bleomycin-induced pulmonary fibrosis (PF), but failed to protect animals from PF induced by TGF-β, and transplantation of bone marrow cells of LRP5-deficient mice could not limit bleomycin-induced fibrosis in LRP5 wild-type mice. This evidence concerns the gene TGFB1 and pulmonary fibrosis.