Increased circulating levels of YKL-40 were reported in fibrotic liver disease: high YKL-40 levels are associated with histologically more severe fibrotic changes in chronic alcoholic hepatitis, primary biliary cirrhosis, autoimmune hepatitis-induced cirrhosis, and hepatitis C [11–14], and YKL-40 was described as a marker of treatment response in interferon-treated patients with hepatitis C [14]. The gene discussed is CHI3L1; the disease is hepatitis C virus infection.