Control subjects had higher baseline RBP4 levels than the liver ICU patients, indicating that stress has a negative impact on RBP4 levels23, whereas the surviving liver ICU patients had higher baseline RBP4 levels than the non-surviving patients, suggesting that RBP4 plays a crucial role in restoring vital functions during crises, even in patients with underlying liver disease, which exerts fundamental effects on RBP4 levels9. The gene discussed is RBP4; the disease is liver disorder.