SLC5A2 and urinary tract infection: The second4, found that urinary tract infections and genital infections were more common with SGLT2 inhibitors compared versus placebo (21 studies, OR 1.34, 95% CI 1.03 to 1.74; 20 studies, OR 3.50, 95% CI 2.46 to 4.99) and active comparators (8 studies, OR 1.42, 95% CI 1.06 to 1.90; 8 studies, OR 5.06, 95% CI 3.44 to 7.45).