EGFR and lymphoma: In contrast, an HL-type diabody constructed from a B-cell–targeting antibody and anti-lymphoma idiotype antibody has higher affinity than the corresponding LH-type diabody45, and for diabodies constructed from humanized anti-EGFR 528 and anti-CD3 OKT3 antibodies, the domain order makes no difference to the affinity to either target21, 46.