ORMDL3 and primary biliary cholangitis: In the present study, in accordance with these previous reports, the PBC- susceptibility allele of rs12946510 showed a lower expression level of ORMDL3, which is possibly followed by lower expression levels of Th2 subset/cytokines and the predominance of other subsets/cytokines of Th in vivo, which are closely associated with the pathogenesis of PBC39.