APP and Alzheimer disease: Remarkably, the Aph1bc cKO Cre+, even when limited to the forebrain pyramidal neurons, has a significant effect on Aβ42 generation (Fig EV3C) confirming previous findings with the Aph1bc full knockout which could prevent amyloidosis and cognitive decline in an APP overexpressing AD model (Serneels et al, 2009).