Three highly ranked genes in these GSEAs are CDK5R1 (neuron-specific activator of cyclin-dependent kinase 5, required for proper development of the central nervous system, also found essential for oligodendrocyte maturation and myelination [26]), BAIAP2 (brain-specific angiogenesis inhibitor binding protein, might be related to neural growth-cone guidance, dendritic spine development and NMDA receptor regulation [27]) and PBX1 (regulates differentiation and survival of certain neurons, and is impaired in Parkinson’s disease [28, 29]). This evidence concerns the gene PBX1 and Parkinson disease.