TF and neoplasm: Predominant genes are FGF2 (implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumour growth [35]), SOX2 or NANOG (TF belonging to Homeobox proteins, critically involved with self-renewal of undifferentiated ESCs, which is also one of Thomson’s reprogramming factors [36]).