Several small, short term studies evaluated insulin effects on lipid subfractions in type 2 diabetes, which showed that insulin treatment was associated with lower concentrations of TG, VLDL, small LDL, and small HDL, as well as increased activity of adipose tissue lipoprotein lipase (LPL) and CETP, and decreased activity of hepatic lipase [26–29, 32]. This evidence concerns the gene LPL and type 2 diabetes mellitus.