In MX-1-bearing mice, a significant reduction in tumour volume was seen from Day 35 onwards in both 1.5 mg/kg DXR HCl liposome injection–treated groups (SPIL product, p < 0.05 vs placebo; reference product p < 0.01 vs placebo; Fig. 1b); from Day 24 and 28 onwards in the 3 mg/kg SPIL and reference DXR HCl liposome injection–treated groups, respectively (both p < 0.05 vs placebo; Fig. 1b); and from Day 21 and 24 onwards in the 6 mg/kg SPIL and reference DXR HCl liposome injection–treated groups, respectively (SPIL product, p < 0.05 vs placebo; reference product p < 0.01 vs placebo; Fig. 1b). The gene discussed is MX1; the disease is neoplasm.