In addition, Sesti et al. (2006) [45] defined secondary sulfonylurea failure as FPG greater than 300 mg/dl despite sulfonylurea-metformin combined therapy and appropriate diet, in the absence of other conditions causing hyperglycemia, but Holstein et al. (2011) [60] defined secondary sulfonylurea failure as the addition of insulin after at least 6-month sulfonylurea therapy and corresponding HbA1c ≥ 7%. The gene discussed is INS; the disease is Hyperglycemia.