The cytotoxicity of the combination of 50 ng/mL TRAIL with 100 μM flavone in SW480 cell line was 83.5 ± 1.3% cell death for 6-AF, 91.4 ± 1.7% cell death for 6-BF, 86.6 ± 0.9% cell death for 7-AF and 90.5 ± 0.8% cell death for 7-BF. This evidence concerns the gene TNFSF10 and atrial fibrillation.