TNFSF10 and colonic neoplasm: In the present study, we examined the cytotoxic and apoptotic effects of recombinant human soluble TRAIL (rhsTRAIL) in combination with nine natural and synthetic flavones: 5-Hydroxyflavone (5-HF) and its derivatives, 5-acetoxyflavone (5-AF) and 5-butyryloxyflavone (5-BF), 6-Hydroxyflavone (6-HF) and its derivatives, 6-acetoxyflavone (6-AF) and 6-butyryloxyflavone (6-BF), and 7-Hydroxyflavone (7-HF) and its derivatives, 7-acetoxyflavone (7-AF) and 7-butyryloxyflavone (7-BF) (Figure 1) in SW480 and SW620 colon cancer cells.