The cytotoxic effect of 100 ng/mL TRAIL with 100 μM flavone against the SW620 cell line increased to 80.8 ± 2.2% cell death for 5-AF, 71.2 ± 2.9% cell death for 7-HF, 90.0 ± 1.1% cell death for 7-AF and 87.8 ± 1.0% cell death for 7-BF. The gene discussed is TNFSF10; the disease is atrial fibrillation.