Pancreatic cancer is characterized by four major driver genes: Kirsten rat sarcoma viral oncogene homolog (KRAS), Cyclin-dependent kinase Inhibitor 2A (CDKN2A), Mothers against decapentaplegic homolog 4 (SMAD4) and Tumor protein p53 (TP53). This evidence concerns the gene SMAD4 and pancreatic neoplasm.