In particular, the NF2 gene encodes Merlin, a member of the band 4.1 family of cytoskeleton-associated proteins, functions as a tumor suppressor and is a critical mediator of contact dependent inhibition of growth through signals from the extracellular matrix and FOXM1/WNT/β-CATENIN pathway in pancreatic cancer [63]. Here, NF2 is linked to familial pancreatic carcinoma.