EZH2 is an oncogene that is upregulated in human epithelial-type cancers such as NSCLC [46,47] and whose expression is inhibited by let-7/miR-98 family members [9], along with that of c-Myc [48], high mobility group AT-hook 2 [49], and LIN28 [17]. Here, EZH2 is linked to cancer.