RETN and obesity due to melanocortin 4 receptor deficiency: Accumulating evidence suggests that n-3 PUFAs from fish oil may counteract the adipokine dysregulation that occurs in obesity and its related diseases like T2DM [9], but it is not well established if the consumption of n-3 PUFAs affects circulating adiponectin, resistin, and leptin in humans; the results are inconclusive [18].