However, it is known that equol and presumably its isomers are potent antioxidants, and evidence exists that it is a stimulator of Nrf2, which plays a key role in the cellular defense against oxidative stress by Nrf2’s capacity to induce the expression of numerous genes, which encode detoxifying enzymes and antioxidant proteins that provide protection in endothelia cells, skin morphogenesis, wound repair and skin cancer [101,102,103,104]. This evidence concerns the gene NFE2L2 and skin cancer.