Improvement in our knowledge of gene mutations in AML has further complicated the baseline prognostic assessment of these patients, that should now include FLT3, NPM1, CEBPA, as well as RUNX1, DNMT3A, IDH1, IDH2, TET2, ASXL1 and TP53 [2,3]. This evidence concerns the gene NPM1 and acute myeloid leukemia.