CDKN3 and chronic hepatitis B virus infection: Interestingly, in chronic hepatitis B (CHB), JMJD6 has been shown to promote cluster of differentiation 4 (CD4+) T-cell proliferation by suppressing cyclin-dependent kinase inhibitor 3 (CDKN3) mRNA expression (which is known to inhibit cell cycle progression by binding to CDK2 kinase) [65].