Immunofluorescent microscopy used to study the movement of JMJD6 from cell membrane to nucleus after infection with JMJD6-FMDV showed failure of internalization of JMJD6 by the mutant virus in the presence of hypertonic sucrose, while nystatin treatment did not impede the JMJD6 internalization. This evidence concerns the gene JMJD6 and infection.