Reviews of experimental manipulations of UHRF1 expression with transfection of short-hairpin UHRF1 RNA or UHRF1 cDNA in colorectal, gastric, glioblastoma, or lung cancer cells [48,152,153], and transfer of subsequent gastric cell lines to athymic mice [152] suggest that by itself, UHRF1 can deregulate tumour suppressor gene expression, induce cancer cell proliferation and migration. The gene discussed is UHRF1; the disease is cancer.