DNMT1 and cancer: The stress-induced changes to the epigenetic marks were coincident with increased 8-oxo-2′-deoxyguanosine (8-oxo-dG) adducts, recruitment of gamma-H2AX (hypothesized to indicate oxidant-induced DNA base damage), and a silencing complex composed of SIRT1 histone deacetylase (a component of PRC4 silencing complex in stem and cancer cells [79]), as well as the PRC2 EZH2 histone3 methyl transferase and its interacting DNMT1 and DNMT3B enzymes.