CDKN2A and astrocytoma (excluding glioblastoma): In line with this interpretation, Boukhari et al. [153] demonstrated that experimental activation or blockage of CD47 (an integrin-associated protein) regulated UHRF1 expression, and subsequently, expression or repression of p16(INK4A) and thus cell proliferation in human astrocytoma cells, but through a mechanism not operating in untransformed astrocytes.