As one example, MLL1 knockdown with antisense oligonucleotides, in the HeLa cervical cancer cell line, resulted in decreased cell cycle progression and decreased expression of various cell-cycle regulatory genes (CYCLIN A and B, p57/KIP2), associated with decreased histone H3K4me3 and RNA polymerase II recruitment at their promoters [108]. This evidence concerns the gene KMT2A and cervical carcinoma.