The increased growth rate of HCC in vitro was related to transcriptional repression due to increased occupancy of PcG components and histone deacetylase 1 (HDAC1) at the promoters of WNT-inhibitor genes, along with relative increases of the H3K27me3 repressive mark and decreases of the H3K9ac activating mark. This evidence concerns the gene HDAC1 and hepatocellular carcinoma.