TGFB1 and neoplasm: In cancers, increased or altered expression of integrins on tumour cells and associated vasculature leads to tumour progression through a wide range of mechanisms, including supporting cell proliferation and tumour angiogenesis as previously mentioned, supporting the epithelial mesenchymal transition [29,30], promoting migration and invasion [31,32,33], interaction with the extracellular microenvironment during the metastatic process [34,35,36], and TGF-β activation facilitating tumour immunosuppression [26,30].