Upregulation of wild-type (wt) EGFR or expression of the EGFR variant III (EGFRvIII) have been associated in U87 glioma cells with promotion of γ-H2AX foci resolution, a surrogate for DSB repair, and with the nuclear accumulation of ATM, DNA-PKcs and RAD51, essential for the activity of NHEJ and HR. This evidence concerns the gene EGFR and central nervous system cancer.