TP53 and hepatocellular carcinoma: However, this can be avoided by using low-frequency and low-energy ultrasound with commercially available microbubbles, a strategy which increased the expression of tumor suppressor gene P53 in PC-3 prostate cancer cells and suppressed the expression of long noncoding activated-RNA by transforming growth factor-β (TGF-β; lncRNA-ATB) in hepatocellular carcinoma (HCC) cells [142,143].