VEGFA and head and neck cancer: In addition to delivering nucleic acids such as siRNA, miRNA or plasmids using photothermal methods, Jung et al. presented an interesting method of enhancing the delivery of oncolytic adenovirus (Ad)-expressing vascular endothelial growth factor (VEGF) promoter-targeted artificial transcriptional repressor zinc-finger protein to head and neck cancer cells by inducing mild hyperthermia using gold nanorods in vitro and in vivo which leads to their cellular uptake [118].