Thus, gaining insight into the function and regulation of particular NF-κB components is crucial for the future development of effective therapies against a wide variety of diseases that involves NF-κB, including diabetes [3,4], allergies and rheumatoid arthritis [5], Crohn’s disease [6], Alzheimer’s disease [7], or cancer, among others. The gene discussed is NFKB1; the disease is Crohn disease.