PGP and parasitic infectious disease: In AIDs patients, P-gp expresses its resistance potential against protease inhibitors, such as indinavir, ritonavir, saquinavir, nelfinavir and it also shows MDR in some parasitic diseases which are caused by Plasmodium falciparum [249], Entamoeba histolytica [250], Leshmania tropica [251], etc. P-gp helps to efflux a wide range of xenobiotics that are taken along with nutrients at the apical membrane of secretory cells like adrenal gland, liver, kidney, placenta, and testes.