There are reports where the development of autoimmunity, arthritis, glomerulonephritis, pulmonary vasculitis among others through the injection of TMPD, are the results of an increased production of cytokines like IL-6, IL-1, IL-12, TNF-α, as well as, the IFN’s receptors that are responsible for releasing a chronic inflammation process [4,30,31,32]. This evidence concerns the gene TNF and arthritic joint disease.