Thereafter, scopoletin was able to stimulate the reactivation of insulin-mediated Akt/PKB phosphorylation, which was greater compared to the positive control rosiglitazone, a thiazolidinedione and activator of PPARγ that markedly improves insulin and glucose parameters in T2DM patients [129]. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.