A study examining 217 neuroblastoma tumors by whole-genome sequencing, including 75 high-risk tumors, found that most high-risk tumors harbored either MYCN amplification, TERT rearrangements or ATRX mutations, all of which can contribute to telomere lengthening and could be useful in the molecular classification of high-risk neuroblastoma [75]. Here, ATRX is linked to neuroblastoma.