MYC and plasma cell myeloma: This technique was successfully used to identify enhancers deregulating MYC expression in B-cells, identifying lineage-specific enhancers located 235 and 535 kb downstream of MYC. Moreover, this region was also identified to be a target of recurrent somatic amplifications in plasma cell myeloma, supporting a role for this enhancer in deregulation of MYC in B-cell malignancies [133] (summarized in Figure 2b).