In addition, we investigated REST level associations with 25 plasma proteins previously associated with either cognitive decline or disease severity.21 REST had a positive correlation with ApoC3 and ApoA1, brain-derived neurotrophic factor (BDNF), regulated on activation, normal T cell expressed and secreted (RANTES), plasminogen activator inhibitor-1 (PAI-1) and neuron-specific enolase (NSE) (Table 2). Here, BDNF is linked to Mental deterioration.