Genes regulated by 4 hr exposures to TNFα and IL1β were highly enriched in the same pathways including, ‘TNF receptor signaling’ (p-values from 1.7e-14 to 1.8e-12), ‘granulocyte adhesion and diapedesis’ (p-values from 2.2e-9 to 7.1e-13), and ‘macrophage, fibroblast and EC roles in rheumatoid arthritis’ (p-values from 2.1e-12 to 1.7e-13). The gene discussed is IL1B; the disease is rheumatoid arthritis.