The second strongest signal that associates with diverticular disease in the Icelandic samples is captured by a single intronic SNP in COLQ, rs7609897-T (chr3:15,461,174, MAF=24.7%) (Fig. 2b), that associates with diverticular disease (OR=0.85, P=1.6 × 10−9) in Iceland; this association replicates nominally in the Danish samples with a consistent direction of the effect (OR=0.91, P=0.010) for a combined OR of 0.87 and P value of 1.5 × 10−10 for the Icelandic and Danish samples. Here, COLQ is linked to diverticular disease.