Frameshift MSI events often display significant tumour-type specificity, for example, MLL3, PRDM2, C9orf114, BAX and OR7E24 are enriched in STAD, JAK1, TFAM and SMC6 are enriched in UCEC, whereas SEC31A, C18orf34, NDUFC2, KIAA1919, CCDC168 and others, are enriched in COAD (P<0.05, one-tailed Fisher's exact test). The gene discussed is JAK1; the disease is neoplasm.