Among these genes (selected on the basis of their association with MSI, DNA repair and colorectal cancer), MSI frameshift events represent a major source for the inactivation of MSH3 and MSH6. In contrast, deleterious SNV mutations more frequently contribute to the loss of function of POLD1 and POLE (27 and 23% of cases, respectively). This evidence concerns the gene MSH3 and colorectal cancer.