Frameshift MSI events often display significant tumour-type specificity, for example, MLL3, PRDM2, C9orf114, BAX and OR7E24 are enriched in STAD, JAK1, TFAM and SMC6 are enriched in UCEC, whereas SEC31A, C18orf34, NDUFC2, KIAA1919, CCDC168 and others, are enriched in COAD (P<0.05, one-tailed Fisher's exact test). This evidence concerns the gene SMC6 and neoplasm.