The L-type Ca2+ channels CaV1.2 (CACNA1C) and CaV1.3 (CACNA1D) are contained in the T2D-associated module and the expression of these genes was strongly correlated with SOX5 in human islets (Pearson correlation r=0.85; P<1E-6 for CACNA1C and r=0.82, P<1E-6, for CACNA1D; n=123). Here, SOX5 is linked to type 2 diabetes mellitus.