Second, we found a significant overlap between the T2D signature and the expression changes induced by knockdown of RORB (GSE16585; P=0.0018; Fisher test), GRN (GSE13162; P=1E-16) and PTCH1 (GSE24628; P=2E-19), respectively, and overexpression of LPAR1 (GSE15263; P=2E-11). This evidence concerns the gene LPAR1 and type 2 diabetes mellitus.