SOX5 and type 2 diabetes mellitus: In islets from db/db mice at 4 weeks of age (when they are still normoglycemic; non-fasting blood glucose 8.0±0.3 mM), Sox5 expression was reduced by 20% and a large fraction of the module genes were changed in a similar direction to that observed in T2D islets (P<1E-6 using Fisher test; 1.4-fold enrichment; Fig. 5b).