Notably, the gene expression changes in response to Sox5-kd were highly similar to those observed in islets from T2D donors relative to non-diabetic donors (same direction of change; Fig. 5a and Supplementary Table 9), whereas the opposite response was observed following Sox5 overexpression (P=0.003; 1.9-fold enrichment of genes having a similar expression change to that in T2D following Sox5-kd and the opposite change after Sox5 overexpression at P<0.05 for both Sox5-kd and Sox5 overexpression). Here, SOX5 is linked to type 2 diabetes mellitus.