CHCHD10 and frontotemporal dementia: To visualize the localization of CHCHD10 and assess mitochondrial integrity secondary to WT or FTD/ALS mutant CHCHD10 expression, we next co-transfected NIH3T3 cells with the mitochondrial marker mito-dsRed and wild-type (WT) or FTD/ALS-linked (R15L or S59L) CHCHD10 variants.