Recent studies have shown the linkage and/or association of multiple CHCHD10 mutations with the spectrum of familial and sporadic FTD–ALS diseases13, 14, 15, 16, 17 as well as the related Charcot–Marie–Tooth disease type 2 (ref. 18) and spinal muscular atrophy Jokela type19 disorders. The gene discussed is CHCHD10; the disease is frontotemporal dementia.