However, despite the role of the FTD/ALS-linked CHCHD10 S59L mutation in reducing mitochondrial length and disorganization of mitochondrial cristae morphology13, neither the normal function of endogenous CHCHD10 nor the nature of the FTD/ALS CHCHD10 mutations has been investigated. This evidence concerns the gene CHCHD10 and amyotrophic lateral sclerosis.