R15L or S59L transduced neurons showed significantly reduced drebrin and synaptophysin puncta compared to empty vector or WT CHCHD10 transduced neurons on DIV21 (Fig. 4c,d), indicating that these FTD/ALS-linked CHCHD10 mutants display a synaptic phenotype similar to that seen with CHCHD10 depletion. This evidence concerns the gene DBN1 and frontotemporal dementia.