The levels of Tim-3 and PD-1 expression on NK cells in the spleen were very low, regardless of the MHC class I expression on tumours, but those in tumour-draining lymph nodes (TdLNs) were slightly increased in mice bearing H-2Kb and H-2Db KO tumours compared with WT tumour-bearing mice, although this increase was not statistically significant (Supplementary Fig. 5). Here, HAVCR2 is linked to neoplasm.