Of note, among the NK cells isolated from MHC class I-deficient tumours, Tim-3+ PD-1+ NK cells exhibited a dramatically reduced expression of effector molecules such as IFN-γ, CD107a, granzyme B and perforin compared with their Tim-3−PD-1− counterparts (Fig. 4b). The gene discussed is HAVCR2; the disease is neoplasm.