ERBB2 and neoplasm: To determine if our previously described bispecific antibody DVD-Ig format (Wu et al., 2007) would efficiently redirect T cells to kill tumor cells in vitro we constructed anti-tumor associated antigen/anti-CD3 DVD-Ig bispecifics to a panel of well-known antigens including CD19, CD20, EGFR, and HER2 (Fig. 1A).