In some tumors, such as glioblastoma, breast cancer, hepatocellular carcinoma and pancreatic cancer, both sAng-1 and sAng-2 are upregulated ((Augustin et al., 2009; Fagiani & Christofori, 2013; Shim, Ho & Wong, 2007; Eklund & Saharinen, 2013). The gene discussed is GNAS-AS1; the disease is familial pancreatic carcinoma.