Previous reports on various type of cancer, such as colorectal cancer, gastric carcinoma, and glioma, have shown that elevated Ang-2 in these tumor cells resulted in increased MVD and stimulated tumor angiogenesis (Augustin et al., 2009; Fagiani & Christofori, 2013; Shim, Ho & Wong, 2007). The gene discussed is ANGPT2; the disease is colorectal cancer.