VEGFA and neoplasm: Both Ang-1 and -2 have recently been found to be expressed in tumor cells, and they act cooperatively with VEGF promoting the angiogenesis during tumor progression (Augustin et al., 2009; Ebos & Kerbel, 2011; Gerald et al., 2013; Shim, Ho & Wong, 2007; Yang et al., 2015).