The ability of sAng-2 concentration and the ratio of sAng-1 to sAng-2 to distinguish between normal, CIN, and cervical cancer was similar to results reported in epithelial ovarian cancer, where the area under the curve for serum Ang-2 in ROC analysis was 0.75 to differentiate ovarian cancer from benign or borderline ovarian tumors (Sallinen et al., 2014; Sallinen et al., 2010). This evidence concerns the gene ANGPT2 and cervical squamous intraepithelial neoplasia.