Consistent with literature data showing the critical roles of hepatic steatosis in tumorigenesis, we also observed that the tumor tissues exhibited a phenotype of significant lipid accumulation and obvious character of primary clear cell carcinoma of the liver (PCCCL) in HBV transgenic mice, which contained the CRISPR/Cas9-mediated Pten loss in livers. This evidence concerns the gene PTEN and hepatocellular clear cell carcinoma.