While previous work on the killing of CD4+ T cells involved a persistent Salmonella infection model compared to the acute infection model used in the present study, the role of activated CD4+CD25+ T cells in inducing an immune response against intracellular bacteria means they represent an obvious target for S. Typhimurium induced killing, even at such an early stage of infection46. This evidence concerns the gene CD4 and Salmonella Infections.