Serum anti-HBc were significantly correlated with liver fibrosis stage in both HBeAg (+) and HBeAg (−) patients (r = 0.233 and 0.240, respectively, P < 0.001), whereas there was no significant difference in the anti-HBc level between fibrosis stage score more than 2 (Fig. 1c,d). This evidence concerns the gene KRT88P and Hepatic fibrosis.