Furthermore, we further divided the recruited patients into the following four groups based on the Asian-Pacific consensus statement on the management of chronic hepatitis B: Low normal group, ALT ≤0.5 × ULN; High normal group, ALT 0.5–1 × ULN; Minimally raised group, ALT 1–2 × ULN and raised groups, ALT >2 × ULN4. The gene discussed is GPT; the disease is chronic hepatitis B virus infection.